Pacing after Phenylpropanolamine (Proin) in dogs

61 reports to the FDA describe pacing in dogs given Phenylpropanolamine. That is 1.5% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

61Reports

44%Marked serious

44%Recovered

3.3%Died or euthanised

Same dayTypical onset

How soon it started

Same day

24 59%

1–2 days

5 12%

3–7 days

4 9.8%

1–4 weeks

1 2.4%

Over a month

7 17%

How the animals did

Recovered

27 44%

Still unwell when reported

12 20%

Euthanised

2 3.3%

Not known

20 33%

Problems reported at the same time

Restlessness or agitation

30 49%

30 49%

23 38%

16 26%

15 25%

15 25%

10 16%

9 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause pacing in dogs?: 61 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pacing with similar medicines

Pacing after Trilostane (Vetoryl) 106 reports · 0.9% of its reports
Pacing after Levothyroxine 36 reports · 1.2% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with pacing