Anxiety after Phenylpropanolamine (Proin) in dogs

101 reports to the FDA describe anxiety in dogs given Phenylpropanolamine. That is 2.4% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

101Reports
42%Marked serious
52%Recovered
5.9%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
38 61%
1–2 days
7 11%
3–7 days
1 1.6%
1–4 weeks
2 3.2%
Over a month
14 23%

How the animals did

Recovered
50 50%
Recovered with lasting effects
3 3.0%
Still unwell when reported
14 14%
Died
2 2.0%
Euthanised
4 4.0%
Not known
28 28%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
16
4–7 years
26
8–11 years
30
12+ years
27

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause anxiety in dogs?
101 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Anxiety with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with anxiety