Nausea after Phenylpropanolamine (Proin) in dogs

The FDA has received 40 reports of nausea in dogs after Phenylpropanolamine. That is 1.0% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

40Reports

53%Marked serious

57%Recovered

10%Died or euthanised

Same dayTypical onset

How soon it started

Same day

18 64%

1–2 days

2 7.1%

3–7 days

3 11%

1–4 weeks

3 11%

Over a month

2 7.1%

How the animals did

Recovered

23 57%

Still unwell when reported

6 15%

Died

1 2.5%

Euthanised

3 7.5%

Not known

7 18%

Problems reported at the same time

Vomiting

21 53%

Loss of appetite

11 28%

Breathing problems

8 20%

Restlessness or agitation

6 15%

6 15%

4 10%

4 10%

4 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause nausea in dogs?: 40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Nausea with similar medicines

Nausea after Trilostane (Vetoryl) 63 reports · 0.5% of its reports
Nausea after Insulin 27 reports · 0.4% of its reports
Nausea after Levothyroxine 24 reports · 0.8% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with nausea