Lameness after Phenylpropanolamine (Proin) in dogs

26 reports to the FDA describe lameness in dogs given Phenylpropanolamine. That is 0.6% of all reports for this medicine, compared with 0.6% across reports for all dog medicines.

26Reports

69%Marked serious

31%Recovered

7.7%Died or euthanised

225 daysTypical onset

How soon it started

Same day

2 14%

1–2 days

1 7.1%

3–7 days

1 7.1%

1–4 weeks

2 14%

Over a month

8 57%

How the animals did

Recovered

5 19%

Recovered with lasting effects

3 12%

Still unwell when reported

10 38%

Died

2 7.7%

Not known

6 23%

Problems reported at the same time

10 38%

6 23%

6 23%

6 23%

5 19%

5 19%

Bone and joint disorder

5 19%

Kidney problems

4 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause lameness in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 225 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lameness with similar medicines

Lameness after Trilostane (Vetoryl) 138 reports · 1.2% of its reports
Lameness after Insulin 50 reports · 0.7% of its reports
Lameness after Levothyroxine 45 reports · 1.5% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with lameness