Lameness after Trilostane (Vetoryl) in dogs

The FDA has received 138 reports of lameness in dogs after Trilostane. That is 1.2% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

138Reports

64%Marked serious

14%Recovered

15%Died or euthanised

47 daysTypical onset

How soon it started

Same day

11 11%

1–2 days

5 5.0%

3–7 days

5 5.0%

1–4 weeks

23 23%

Over a month

57 56%

How the animals did

Recovered

20 14%

Still unwell when reported

21 15%

Died

2 1.4%

Euthanised

19 14%

Not known

76 55%

Problems reported at the same time

41 30%

38 28%

35 25%

27 20%

21 15%

19 14%

18 13%

17 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause lameness in dogs?: 138 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 47 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lameness with similar medicines

Lameness after Insulin 50 reports · 0.7% of its reports
Lameness after Phenylpropanolamine (Proin) 26 reports · 0.6% of its reports
Lameness after Levothyroxine 45 reports · 1.5% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with lameness