Disorientation after Phenylpropanolamine (Proin) in dogs

76 reports to the FDA describe disorientation in dogs given Phenylpropanolamine. That is 1.8% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

76Reports

47%Marked serious

46%Recovered

20%Died or euthanised

1 daysTypical onset

How soon it started

Same day

22 43%

1–2 days

11 22%

3–7 days

1 2.0%

1–4 weeks

6 12%

Over a month

11 22%

How the animals did

Recovered

35 46%

Still unwell when reported

8 11%

Died

5 6.6%

Euthanised

10 13%

Not known

18 24%

Problems reported at the same time

27 36%

24 32%

21 28%

17 22%

16 21%

15 20%

14 18%

10 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause disorientation in dogs?: 76 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

Disorientation after Trilostane (Vetoryl) 167 reports · 1.4% of its reports
Disorientation after Insulin 137 reports · 1.9% of its reports
Disorientation after Levothyroxine 61 reports · 2.0% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with disorientation