Disorientation after Trilostane (Vetoryl) in dogs

The FDA has received 167 reports of disorientation in dogs after Trilostane. That is 1.4% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

167Reports

58%Marked serious

18%Recovered

20%Died or euthanised

32 daysTypical onset

How soon it started

Same day

6 4.8%

1–2 days

10 8.0%

3–7 days

10 8.0%

1–4 weeks

32 26%

Over a month

67 54%

How the animals did

Recovered

29 17%

Recovered with lasting effects

1 0.6%

Still unwell when reported

18 11%

Died

5 3.0%

Euthanised

28 17%

Not known

86 51%

Problems reported at the same time

60 36%

59 35%

45 27%

34 20%

31 19%

28 17%

27 16%

26 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause disorientation in dogs?: 167 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 32 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

Disorientation after Insulin 137 reports · 1.9% of its reports
Disorientation after Phenylpropanolamine (Proin) 76 reports · 1.8% of its reports
Disorientation after Levothyroxine 61 reports · 2.0% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with disorientation