Dehydration after Phenylpropanolamine (Proin) in dogs

The FDA has received 54 reports of dehydration in dogs after Phenylpropanolamine. That is 1.3% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

54Reports

89%Marked serious

39%Recovered

30%Died or euthanised

1 daysTypical onset

How soon it started

Same day

15 44%

1–2 days

6 18%

3–7 days

2 5.9%

1–4 weeks

5 15%

Over a month

6 18%

How the animals did

Recovered

20 37%

Recovered with lasting effects

1 1.9%

Still unwell when reported

4 7.4%

Died

5 9.3%

Euthanised

11 20%

Not known

13 24%

Problems reported at the same time

29 54%

28 52%

22 41%

21 39%

15 28%

15 28%

13 24%

10 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause dehydration in dogs?: 54 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dehydration with similar medicines

Dehydration after Trilostane (Vetoryl) 195 reports · 1.6% of its reports
Dehydration after Insulin 106 reports · 1.4% of its reports
Dehydration after Levothyroxine 32 reports · 1.1% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with dehydration