Dehydration after Trilostane (Vetoryl) in dogs

195 reports to the FDA describe dehydration in dogs given Trilostane. That is 1.6% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

195Reports

85%Marked serious

9.7%Recovered

32%Died or euthanised

30 daysTypical onset

How soon it started

Same day

5 3.3%

1–2 days

16 11%

3–7 days

22 15%

1–4 weeks

33 22%

Over a month

75 50%

How the animals did

Recovered

18 9.2%

Recovered with lasting effects

1 0.5%

Still unwell when reported

35 18%

Died

25 13%

Euthanised

38 19%

Not known

78 40%

Problems reported at the same time

135 69%

108 55%

104 53%

100 51%

77 39%

72 37%

63 32%

50 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

104

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause dehydration in dogs?: 195 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 30 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dehydration with similar medicines

Dehydration after Insulin 106 reports · 1.4% of its reports
Dehydration after Phenylpropanolamine (Proin) 54 reports · 1.3% of its reports
Dehydration after Levothyroxine 32 reports · 1.1% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with dehydration