Nausea after Oclacitinib (Apoquel) in dogs

The FDA has received 130 reports of nausea in dogs after Oclacitinib. That is 0.4% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

130Reports

42%Marked serious

18%Recovered

8.5%Died or euthanised

3 daysTypical onset

How soon it started

Same day

39 36%

1–2 days

14 13%

3–7 days

7 6.5%

1–4 weeks

21 20%

Over a month

26 24%

How the animals did

Recovered

23 18%

Still unwell when reported

67 52%

Died

1 0.8%

Euthanised

10 7.7%

Not known

29 22%

Problems reported at the same time

52 40%

51 39%

43 33%

25 19%

20 15%

Didn't work as expected

17 13%

Liver problems

15 12%

Behaviour change

14 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause nausea in dogs?: 130 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Nausea with similar medicines

Nausea after Cyclosporine (Atopica) 149 reports · 1.0% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with nausea