Walking difficulty after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

34 reports to the FDA describe walking difficulty in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

34Reports

65%Marked serious

35%Recovered

15%Died or euthanised

Same dayTypical onset

How soon it started

Same day

11 52%

1–2 days

4 19%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

6 29%

How the animals did

Recovered

12 35%

Still unwell when reported

11 32%

Died

1 2.9%

Euthanised

4 12%

Not known

6 18%

Problems reported at the same time

15 44%

11 32%

10 29%

7 21%

7 21%

7 21%

6 18%

6 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause walking difficulty in dogs?: 34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Walking difficulty with similar medicines

Walking difficulty after Spinosad (Comfortis) 148 reports · 0.3% of its reports
Walking difficulty after Lufenuron + Milbemycin Oxime (Sentinel) 53 reports · 0.2% of its reports
Walking difficulty after Imidacloprid + Moxidectin (Advantage Multi) 36 reports · 0.3% of its reports
Walking difficulty after Nitenpyram (Capstar) 53 reports · 0.5% of its reports
Walking difficulty after Fipronil + S-methoprene (Frontline Plus) 25 reports · 0.8% of its reports
Walking difficulty after Imidacloprid 29 reports · 1.5% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with walking difficulty