Walking difficulty after Imidacloprid + Moxidectin (Advantage Multi) in dogs

The FDA has received 36 reports of walking difficulty in dogs after Imidacloprid + Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

36Reports

81%Marked serious

44%Recovered

5.6%Died or euthanised

1 daysTypical onset

How soon it started

Same day

9 35%

1–2 days

11 42%

3–7 days

0 0.0%

1–4 weeks

5 19%

Over a month

1 3.8%

How the animals did

Recovered

16 44%

Still unwell when reported

6 17%

Died

2 5.6%

Not known

12 33%

Problems reported at the same time

16 44%

13 36%

8 22%

8 22%

8 22%

8 22%

6 17%

4 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause walking difficulty in dogs?: 36 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Walking difficulty with similar medicines

Walking difficulty after Spinosad (Comfortis) 148 reports · 0.3% of its reports
Walking difficulty after Lufenuron + Milbemycin Oxime (Sentinel) 53 reports · 0.2% of its reports
Walking difficulty after Nitenpyram (Capstar) 53 reports · 0.5% of its reports
Walking difficulty after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 34 reports · 0.3% of its reports
Walking difficulty after Fipronil + S-methoprene (Frontline Plus) 25 reports · 0.8% of its reports
Walking difficulty after Imidacloprid 29 reports · 1.5% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with walking difficulty