Walking difficulty after Fipronil + S-methoprene (Frontline Plus) in dogs

The FDA has received 25 reports of walking difficulty in dogs after Fipronil + S-methoprene. That is 0.8% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Fipronil kills fleas and ticks (spot-on).

Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Fipronil + S-methoprene cause walking difficulty in dogs?

25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 18 days of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Walking difficulty with similar medicines

• Walking difficulty after Spinosad (Comfortis) 148 reports · 0.3% of its reports
• Walking difficulty after Lufenuron + Milbemycin Oxime (Sentinel) 53 reports · 0.2% of its reports
• Walking difficulty after Imidacloprid + Moxidectin (Advantage Multi) 36 reports · 0.3% of its reports
• Walking difficulty after Nitenpyram (Capstar) 53 reports · 0.5% of its reports
• Walking difficulty after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 34 reports · 0.3% of its reports
• Walking difficulty after Imidacloprid 29 reports · 1.5% of its reports

All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with walking difficulty