Drug administration error after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 48 reports of drug administration error in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.5% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

48Reports

54%Marked serious

40%Recovered

2.1%Died or euthanised

Same dayTypical onset

How soon it started

Same day

10 53%

1–2 days

3 16%

3–7 days

2 11%

1–4 weeks

0 0.0%

Over a month

4 21%

How the animals did

Recovered

19 40%

Still unwell when reported

26 54%

Died

1 2.1%

Not known

2 4.2%

Problems reported at the same time

Vomiting

17 35%

Didn't prevent heartworm

10 21%

8 17%

6 13%

4 8.3%

3 6.3%

3 6.3%

3 6.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause drug administration error in dogs?: 48 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug administration error with similar medicines

Drug administration error after Spinosad (Comfortis) 164 reports · 0.3% of its reports
Drug administration error after Lufenuron + Milbemycin Oxime (Sentinel) 47 reports · 0.2% of its reports
Drug administration error after Imidacloprid + Moxidectin (Advantage Multi) 105 reports · 0.8% of its reports
Drug administration error after Nitenpyram (Capstar) 63 reports · 0.6% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with drug administration error