Digestive tract disorder after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 33 reports of digestive tract disorder in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.3% of all reports for this medicine, compared with 2.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

33Reports

61%Marked serious

39%Recovered

0.0%Died or euthanised

13 daysTypical onset

How soon it started

Same day

3 17%

1–2 days

2 11%

3–7 days

2 11%

1–4 weeks

9 50%

Over a month

2 11%

How the animals did

Recovered

13 39%

Still unwell when reported

4 12%

Not known

16 48%

Problems reported at the same time

Didn't work as expected

15 45%

14 42%

14 42%

13 39%

13 39%

9 27%

Abnormal radiograph finding

7 21%

Weight loss

4 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause digestive tract disorder in dogs?: 33 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 13 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Digestive tract disorder with similar medicines

Digestive tract disorder after Spinosad (Comfortis) 141 reports · 0.2% of its reports
Digestive tract disorder after Lufenuron + Milbemycin Oxime (Sentinel) 108 reports · 0.4% of its reports
Digestive tract disorder after Imidacloprid + Moxidectin (Advantage Multi) 46 reports · 0.4% of its reports
Digestive tract disorder after Nitenpyram (Capstar) 30 reports · 0.3% of its reports
Digestive tract disorder after Fipronil + S-methoprene (Frontline Plus) 27 reports · 0.9% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with digestive tract disorder