Digestive tract disorder after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

108 reports to the FDA describe digestive tract disorder in dogs given Lufenuron + Milbemycin Oxime. That is 0.4% of all reports for this medicine, compared with 2.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

108Reports

38%Marked serious

19%Recovered

11%Died or euthanised

13 daysTypical onset

How soon it started

Same day

6 19%

1–2 days

5 16%

3–7 days

2 6.3%

1–4 weeks

7 22%

Over a month

12 38%

How the animals did

Recovered

21 19%

Still unwell when reported

8 7.4%

Died

7 6.5%

Euthanised

5 4.6%

Not known

67 62%

Problems reported at the same time

44 41%

38 35%

32 30%

30 28%

24 22%

Didn't work as expected

23 21%

Abnormal radiograph finding

19 18%

Death

13 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause digestive tract disorder in dogs?: 108 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 13 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Digestive tract disorder with similar medicines

Digestive tract disorder after Spinosad (Comfortis) 141 reports · 0.2% of its reports
Digestive tract disorder after Imidacloprid + Moxidectin (Advantage Multi) 46 reports · 0.4% of its reports
Digestive tract disorder after Nitenpyram (Capstar) 30 reports · 0.3% of its reports
Digestive tract disorder after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 33 reports · 0.3% of its reports
Digestive tract disorder after Fipronil + S-methoprene (Frontline Plus) 27 reports · 0.9% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with digestive tract disorder