Increased percentage reticulocytes after Leptospirosis Vaccine in dogs

The FDA has received 55 reports of increased percentage reticulocytes in dogs after Leptospirosis Vaccine. That is 0.7% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

55Reports
80%Marked serious
7.3%Recovered
27%Died or euthanised
21 daysTypical onset
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How soon it started

Same day
5 11%
1–2 days
2 4.3%
3–7 days
10 21%
1–4 weeks
12 26%
Over a month
18 38%

How the animals did

Recovered
4 7.3%
Still unwell when reported
23 42%
Died
7 13%
Euthanised
8 15%
Not known
13 24%

Problems reported at the same time

Liver problems
34 62%
Lethargy
33 60%
Blood problems
32 58%
Loss of appetite
29 53%
Leucocytosis
25 45%
Neutrophilia
25 45%
Vomiting
21 38%
Monocytosis
17 31%

Age of the animals

Under 1 year
5
1–3 years
10
4–7 years
21
8–11 years
15
12+ years
3

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause increased percentage reticulocytes in dogs?
55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 21 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Increased percentage reticulocytes with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with increased percentage reticulocytes