Hyperphosphataemia after Leptospirosis Vaccine in dogs

116 reports to the FDA describe hyperphosphataemia in dogs given Leptospirosis Vaccine. That is 1.4% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

116Reports
88%Marked serious
3.4%Recovered
48%Died or euthanised
12 daysTypical onset
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How soon it started

Same day
21 24%
1–2 days
14 16%
3–7 days
4 4.5%
1–4 weeks
21 24%
Over a month
29 33%

How the animals did

Recovered
4 3.4%
Still unwell when reported
41 35%
Died
17 15%
Euthanised
39 34%
Not known
15 13%

Problems reported at the same time

Age of the animals

Under 1 year
26
1–3 years
17
4–7 years
21
8–11 years
25
12+ years
27

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause hyperphosphataemia in dogs?
116 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 12 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperphosphataemia with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with hyperphosphataemia