Hypercalcaemia after Leptospirosis Vaccine in dogs

34 reports to the FDA describe hypercalcaemia in dogs given Leptospirosis Vaccine. That is 0.4% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

34Reports

76%Marked serious

12%Recovered

44%Died or euthanised

12 daysTypical onset

How soon it started

Same day

6 25%

1–2 days

5 21%

3–7 days

1 4.2%

1–4 weeks

4 17%

Over a month

8 33%

How the animals did

Recovered

4 12%

Still unwell when reported

13 38%

Died

4 12%

Euthanised

11 32%

Not known

2 5.9%

Problems reported at the same time

22 65%

21 62%

18 53%

17 50%

17 50%

15 44%

14 41%

12 35%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause hypercalcaemia in dogs?: 34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 12 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypercalcaemia with similar medicines

Hypercalcaemia after Rabies Vaccine 30 reports · 0.3% of its reports
Hypercalcaemia after Bordetella Vaccine 29 reports · 0.3% of its reports
Hypercalcaemia after Distemper-parvo Vaccine 23 reports · 0.4% of its reports

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with hypercalcaemia