Elevated amylase after Leptospirosis Vaccine in dogs

63 reports to the FDA describe elevated amylase in dogs given Leptospirosis Vaccine. That is 0.8% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

63Reports

83%Marked serious

7.9%Recovered

46%Died or euthanised

16 daysTypical onset

How soon it started

Same day

10 24%

1–2 days

3 7.3%

3–7 days

6 15%

1–4 weeks

4 9.8%

Over a month

18 44%

How the animals did

Recovered

5 7.9%

Still unwell when reported

21 33%

Died

9 14%

Euthanised

20 32%

Not known

8 13%

Problems reported at the same time

40 63%

40 63%

34 54%

33 52%

33 52%

31 49%

29 46%

18 29%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause elevated amylase in dogs?: 63 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 16 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated amylase with similar medicines

Elevated amylase after Rabies Vaccine 78 reports · 0.8% of its reports
Elevated amylase after Bordetella Vaccine 51 reports · 0.5% of its reports
Elevated amylase after Distemper-parvo Vaccine 50 reports · 0.8% of its reports

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with elevated amylase