Decreased packed cell volume (pcv) after Leptospirosis Vaccine in dogs

61 reports to the FDA describe decreased packed cell volume (pcv) in dogs given Leptospirosis Vaccine. That is 0.8% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

61Reports
92%Marked serious
6.6%Recovered
41%Died or euthanised
15 daysTypical onset
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How soon it started

Same day
7 13%
1–2 days
9 17%
3–7 days
5 9.6%
1–4 weeks
13 25%
Over a month
18 35%

How the animals did

Recovered
4 6.6%
Still unwell when reported
24 39%
Died
5 8.2%
Euthanised
20 33%
Not known
8 13%

Problems reported at the same time

Blood problems
45 74%
Lethargy
34 56%
Loss of appetite
33 54%
Death
25 41%
Liver problems
24 39%
Vomiting
24 39%
Leucocytosis
18 30%
Diarrhea
15 25%

Age of the animals

Under 1 year
10
1–3 years
11
4–7 years
19
8–11 years
16
12+ years
4

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause decreased packed cell volume (pcv) in dogs?
61 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 15 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased packed cell volume (pcv) with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with decreased packed cell volume (pcv)