Behaviour change after Leptospirosis Vaccine in dogs

296 reports to the FDA describe behaviour change in dogs given Leptospirosis Vaccine. That is 3.7% of all reports for this medicine, compared with 2.5% across reports for all dog medicines.

296Reports

60%Marked serious

22%Recovered

16%Died or euthanised

4 daysTypical onset

How soon it started

Same day

67 28%

1–2 days

39 16%

3–7 days

28 12%

1–4 weeks

42 18%

Over a month

61 26%

How the animals did

Recovered

60 20%

Recovered with lasting effects

4 1.4%

Still unwell when reported

102 34%

Died

23 7.8%

Euthanised

24 8.1%

Not known

83 28%

Problems reported at the same time

109 37%

103 35%

94 32%

46 16%

44 15%

42 14%

42 14%

41 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause behaviour change in dogs?: 296 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

Behaviour change after Rabies Vaccine 406 reports · 4.1% of its reports
Behaviour change after Bordetella Vaccine 355 reports · 3.8% of its reports
Behaviour change after Lyme Vaccine 82 reports · 1.2% of its reports
Behaviour change after Distemper-parvo Vaccine 296 reports · 4.6% of its reports

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with behaviour change