Injection site reaction after Amoxicillin + Clavulanate (Clavamox) in dogs

165 reports to the FDA describe injection site reaction in dogs given Amoxicillin + Clavulanate. That is 3.1% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

165Reports
41%Marked serious
12%Recovered
13%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
19 15%
1–2 days
21 16%
3–7 days
26 20%
1–4 weeks
46 35%
Over a month
19 15%

How the animals did

Recovered
19 12%
Recovered with lasting effects
1 0.6%
Still unwell when reported
83 50%
Died
13 7.9%
Euthanised
8 4.8%
Not known
41 25%

Problems reported at the same time

Age of the animals

Under 1 year
38
1–3 years
29
4–7 years
40
8–11 years
37
12+ years
19

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause injection site reaction in dogs?
165 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with injection site reaction