Swelling after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 454 reports of swelling in dogs after Amoxicillin + Clavulanate. That is 8.4% of all reports for this medicine, compared with 2.8% across reports for all dog medicines, so it is reported unusually often with this medicine.

454Reports

45%Marked serious

13%Recovered

19%Died or euthanised

5 daysTypical onset

How soon it started

Same day

55 19%

1–2 days

57 19%

3–7 days

55 19%

1–4 weeks

80 27%

Over a month

48 16%

How the animals did

Recovered

58 13%

Recovered with lasting effects

1 0.2%

Still unwell when reported

162 36%

Died

49 11%

Euthanised

38 8.4%

Not known

146 32%

Problems reported at the same time

132 29%

130 29%

93 20%

86 19%

85 19%

81 18%

72 16%

Didn't work as expected

70 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

103

8–11 years

111

12+ years

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause swelling in dogs?: 454 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

Swelling after Doxycycline 288 reports · 7.2% of its reports
Swelling after Cefovecin (Convenia) 362 reports · 9.6% of its reports
Swelling after Enrofloxacin (Baytril) 323 reports · 8.6% of its reports
Swelling after Metronidazole 238 reports · 7.7% of its reports
Swelling after Amoxicillin 76 reports · 5.6% of its reports

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with swelling