Lethargy after Amoxicillin + Clavulanate (Clavamox) in dogs

1,070 reports to the FDA describe lethargy in dogs given Amoxicillin + Clavulanate. That is 20% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,070Reports
46%Marked serious
13%Recovered
26%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
128 18%
1–2 days
119 17%
3–7 days
139 20%
1–4 weeks
155 22%
Over a month
151 22%

How the animals did

Recovered
125 12%
Recovered with lasting effects
10 0.9%
Still unwell when reported
337 31%
Died
160 15%
Euthanised
122 11%
Not known
316 30%

Problems reported at the same time

425 40%
283 26%
183 17%
176 16%

Age of the animals

Under 1 year
161
1–3 years
172
4–7 years
263
8–11 years
282
12+ years
177

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause lethargy in dogs?
1,070 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with lethargy