Lethargy after Amoxicillin in dogs

The FDA has received 344 reports of lethargy in dogs after Amoxicillin. That is 26% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported unusually often with this medicine.

344Reports

67%Marked serious

18%Recovered

31%Died or euthanised

8 daysTypical onset

How soon it started

Same day

43 16%

1–2 days

37 13%

3–7 days

54 19%

1–4 weeks

71 26%

Over a month

72 26%

How the animals did

Recovered

60 17%

Recovered with lasting effects

2 0.6%

Still unwell when reported

110 32%

Died

41 12%

Euthanised

64 19%

Not known

67 19%

Problems reported at the same time

191 56%

151 44%

134 39%

103 30%

69 20%

68 20%

59 17%

58 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

111

12+ years

About this medicine

Amoxicillin treats bacterial infections.

Questions owners ask

Can Amoxicillin cause lethargy in dogs?: 344 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

Lethargy after Amoxicillin + Clavulanate (Clavamox) 1,070 reports · 20% of its reports
Lethargy after Doxycycline 677 reports · 17% of its reports
Lethargy after Cefovecin (Convenia) 936 reports · 25% of its reports
Lethargy after Enrofloxacin (Baytril) 795 reports · 21% of its reports
Lethargy after Metronidazole 798 reports · 26% of its reports

All reported side effects of Amoxicillin in dogs · Medicines most reported with lethargy