Liver problems after Amoxicillin in dogs

The FDA has received 307 reports of liver problems in dogs after Amoxicillin. That is 23% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

307Reports
66%Marked serious
9.1%Recovered
29%Died or euthanised
12 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
25 11%
1–2 days
22 9.9%
3–7 days
37 17%
1–4 weeks
69 31%
Over a month
70 31%

How the animals did

Recovered
24 7.8%
Recovered with lasting effects
4 1.3%
Still unwell when reported
123 40%
Died
31 10%
Euthanised
59 19%
Not known
66 21%

Problems reported at the same time

Loss of appetite
156 51%
Vomiting
147 48%
Lethargy
134 44%
Death
90 29%
Kidney problems
88 29%
Leucocytosis
69 22%
Diarrhea
60 20%
Abnormal ultrasound finding
58 19%

Age of the animals

Under 1 year
15
1–3 years
31
4–7 years
69
8–11 years
128
12+ years
61

About this medicine

Amoxicillin treats bacterial infections.

Questions owners ask

Can Amoxicillin cause liver problems in dogs?
307 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 12 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Amoxicillin in dogs · Medicines most reported with liver problems