Liver problems after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 816 reports of liver problems in dogs after Amoxicillin + Clavulanate. That is 15% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

816Reports
50%Marked serious
6.3%Recovered
31%Died or euthanised
11 daysTypical onset
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How soon it started

Same day
54 11%
1–2 days
80 16%
3–7 days
86 17%
1–4 weeks
131 27%
Over a month
142 29%

How the animals did

Recovered
44 5.4%
Recovered with lasting effects
7 0.9%
Still unwell when reported
266 33%
Died
129 16%
Euthanised
125 15%
Not known
245 30%

Problems reported at the same time

Age of the animals

Under 1 year
49
1–3 years
88
4–7 years
237
8–11 years
252
12+ years
183

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause liver problems in dogs?
816 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 11 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with liver problems