Leucocytosis after Amoxicillin + Clavulanate (Clavamox) in dogs

349 reports to the FDA describe leucocytosis in dogs given Amoxicillin + Clavulanate. That is 6.5% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

349Reports
57%Marked serious
6.6%Recovered
37%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
35 15%
1–2 days
39 17%
3–7 days
47 20%
1–4 weeks
67 29%
Over a month
42 18%

How the animals did

Recovered
20 5.7%
Recovered with lasting effects
3 0.9%
Still unwell when reported
118 34%
Died
67 19%
Euthanised
61 17%
Not known
80 23%

Problems reported at the same time

Age of the animals

Under 1 year
66
1–3 years
55
4–7 years
88
8–11 years
87
12+ years
52

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause leucocytosis in dogs?
349 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with leucocytosis