Leucocytosis after Doxycycline in dogs

The FDA has received 210 reports of leucocytosis in dogs after Doxycycline. That is 5.2% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

210Reports

83%Marked serious

9.5%Recovered

40%Died or euthanised

18 daysTypical onset

How soon it started

Same day

19 11%

1–2 days

12 7.1%

3–7 days

27 16%

1–4 weeks

52 31%

Over a month

60 35%

How the animals did

Recovered

18 8.6%

Recovered with lasting effects

2 1.0%

Still unwell when reported

84 40%

Died

33 16%

Euthanised

52 25%

Not known

21 10%

Problems reported at the same time

127 60%

124 59%

111 53%

105 50%

94 45%

85 40%

78 37%

67 32%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause leucocytosis in dogs?: 210 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 18 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

Leucocytosis after Amoxicillin + Clavulanate (Clavamox) 349 reports · 6.5% of its reports
Leucocytosis after Cefovecin (Convenia) 175 reports · 4.6% of its reports
Leucocytosis after Enrofloxacin (Baytril) 222 reports · 5.9% of its reports
Leucocytosis after Metronidazole 199 reports · 6.4% of its reports
Leucocytosis after Amoxicillin 102 reports · 7.6% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with leucocytosis