Blood problems after Doxycycline in dogs

The FDA has received 385 reports of blood problems in dogs after Doxycycline. That is 9.6% of all reports for this medicine, compared with 1.8% across reports for all dog medicines, so it is reported unusually often with this medicine.

385Reports

86%Marked serious

6.8%Recovered

46%Died or euthanised

19 daysTypical onset

How soon it started

Same day

32 10%

1–2 days

28 8.9%

3–7 days

48 15%

1–4 weeks

75 24%

Over a month

132 42%

How the animals did

Recovered

26 6.8%

Still unwell when reported

144 37%

Died

62 16%

Euthanised

117 30%

Not known

36 9.4%

Problems reported at the same time

219 57%

193 50%

181 47%

179 46%

121 31%

111 29%

98 25%

97 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

131

8–11 years

129

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause blood problems in dogs?: 385 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 19 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood problems with similar medicines

Blood problems after Amoxicillin + Clavulanate (Clavamox) 499 reports · 9.3% of its reports
Blood problems after Cefovecin (Convenia) 322 reports · 8.5% of its reports
Blood problems after Enrofloxacin (Baytril) 279 reports · 7.4% of its reports
Blood problems after Metronidazole 307 reports · 9.9% of its reports
Blood problems after Amoxicillin 111 reports · 8.2% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with blood problems