Neutrophilia after Doxycycline in dogs

The FDA has received 165 reports of neutrophilia in dogs after Doxycycline. That is 4.1% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

165Reports

85%Marked serious

8.5%Recovered

39%Died or euthanised

17 daysTypical onset

How soon it started

Same day

15 11%

1–2 days

11 8.3%

3–7 days

25 19%

1–4 weeks

37 28%

Over a month

44 33%

How the animals did

Recovered

13 7.9%

Recovered with lasting effects

1 0.6%

Still unwell when reported

66 40%

Died

21 13%

Euthanised

44 27%

Not known

20 12%

Problems reported at the same time

104 63%

98 59%

98 59%

94 57%

92 56%

65 39%

61 37%

47 28%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause neutrophilia in dogs?: 165 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 17 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutrophilia with similar medicines

Neutrophilia after Amoxicillin + Clavulanate (Clavamox) 231 reports · 4.3% of its reports
Neutrophilia after Cefovecin (Convenia) 111 reports · 2.9% of its reports
Neutrophilia after Enrofloxacin (Baytril) 156 reports · 4.1% of its reports
Neutrophilia after Metronidazole 168 reports · 5.4% of its reports
Neutrophilia after Amoxicillin 67 reports · 5.0% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with neutrophilia