Monocytosis after Doxycycline in dogs

101 reports to the FDA describe monocytosis in dogs given Doxycycline. That is 2.5% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

101Reports

87%Marked serious

7.9%Recovered

38%Died or euthanised

16 daysTypical onset

How soon it started

Same day

2 2.7%

1–2 days

9 12%

3–7 days

15 21%

1–4 weeks

22 30%

Over a month

25 34%

How the animals did

Recovered

7 6.9%

Recovered with lasting effects

1 1.0%

Still unwell when reported

44 44%

Died

12 12%

Euthanised

26 26%

Not known

11 11%

Problems reported at the same time

70 69%

64 63%

62 61%

61 60%

56 55%

48 48%

38 38%

37 37%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause monocytosis in dogs?: 101 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 16 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Monocytosis with similar medicines

Monocytosis after Amoxicillin + Clavulanate (Clavamox) 110 reports · 2.0% of its reports
Monocytosis after Cefovecin (Convenia) 47 reports · 1.2% of its reports
Monocytosis after Enrofloxacin (Baytril) 94 reports · 2.5% of its reports
Monocytosis after Metronidazole 92 reports · 3.0% of its reports
Monocytosis after Amoxicillin 31 reports · 2.3% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with monocytosis