Monocytosis after Amoxicillin in dogs

31 reports to the FDA describe monocytosis in dogs given Amoxicillin. That is 2.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

31Reports

81%Marked serious

6.5%Recovered

45%Died or euthanised

10 daysTypical onset

How soon it started

Same day

4 17%

1–2 days

4 17%

3–7 days

3 13%

1–4 weeks

9 38%

Over a month

4 17%

How the animals did

Recovered

2 6.5%

Still unwell when reported

5 16%

Died

4 13%

Euthanised

10 32%

Not known

10 32%

Problems reported at the same time

23 74%

23 74%

21 68%

17 55%

16 52%

15 48%

14 45%

12 39%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Amoxicillin treats bacterial infections.

Questions owners ask

Can Amoxicillin cause monocytosis in dogs?: 31 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 10 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Monocytosis with similar medicines

Monocytosis after Amoxicillin + Clavulanate (Clavamox) 110 reports · 2.0% of its reports
Monocytosis after Doxycycline 101 reports · 2.5% of its reports
Monocytosis after Cefovecin (Convenia) 47 reports · 1.2% of its reports
Monocytosis after Enrofloxacin (Baytril) 94 reports · 2.5% of its reports
Monocytosis after Metronidazole 92 reports · 3.0% of its reports

All reported side effects of Amoxicillin in dogs · Medicines most reported with monocytosis