Monocytosis after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 110 reports of monocytosis in dogs after Amoxicillin + Clavulanate. That is 2.0% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

110Reports
73%Marked serious
12%Recovered
31%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
7 7.4%
1–2 days
18 19%
3–7 days
23 24%
1–4 weeks
24 26%
Over a month
22 23%

How the animals did

Recovered
13 12%
Still unwell when reported
44 40%
Died
13 12%
Euthanised
21 19%
Not known
19 17%

Problems reported at the same time

Age of the animals

Under 1 year
18
1–3 years
18
4–7 years
32
8–11 years
32
12+ years
10

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause monocytosis in dogs?
110 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Monocytosis with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with monocytosis