Neutrophilia after Amoxicillin + Clavulanate (Clavamox) in dogs

231 reports to the FDA describe neutrophilia in dogs given Amoxicillin + Clavulanate. That is 4.3% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

231Reports
69%Marked serious
5.6%Recovered
33%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
19 10%
1–2 days
34 19%
3–7 days
40 22%
1–4 weeks
48 26%
Over a month
42 23%

How the animals did

Recovered
12 5.2%
Recovered with lasting effects
1 0.4%
Still unwell when reported
106 46%
Died
37 16%
Euthanised
39 17%
Not known
36 16%

Problems reported at the same time

Age of the animals

Under 1 year
36
1–3 years
32
4–7 years
64
8–11 years
65
12+ years
33

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause neutrophilia in dogs?
231 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutrophilia with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with neutrophilia