Liver problems after Metronidazole in dogs

645 reports to the FDA describe liver problems in dogs given Metronidazole. That is 21% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

645Reports
75%Marked serious
11%Recovered
35%Died or euthanised
10 daysTypical onset
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How soon it started

Same day
83 15%
1–2 days
79 15%
3–7 days
84 16%
1–4 weeks
134 25%
Over a month
156 29%

How the animals did

Recovered
60 9.3%
Recovered with lasting effects
8 1.2%
Still unwell when reported
272 42%
Died
69 11%
Euthanised
159 25%
Not known
77 12%

Problems reported at the same time

Age of the animals

Under 1 year
44
1–3 years
94
4–7 years
149
8–11 years
211
12+ years
146

About this medicine

Metronidazole treats some bacterial and parasitic gut infections.

Questions owners ask

Can Metronidazole cause liver problems in dogs?
645 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 10 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Metronidazole in dogs · Medicines most reported with liver problems