Didn't work as expected after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 1,093 reports of didn't work as expected in dogs after Amoxicillin + Clavulanate. That is 20% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,093Reports

30%Marked serious

6.2%Recovered

8.7%Died or euthanised

17 daysTypical onset

How soon it started

Same day

68 12%

1–2 days

63 11%

3–7 days

64 11%

1–4 weeks

170 29%

Over a month

214 37%

How the animals did

Recovered

62 5.7%

Recovered with lasting effects

6 0.5%

Still unwell when reported

454 42%

Died

47 4.3%

Euthanised

48 4.4%

Not known

476 44%

Problems reported at the same time

150 14%

137 13%

130 12%

96 8.8%

88 8.1%

71 6.5%

71 6.5%

70 6.4%

Age of the animals

Under 1 year

231

1–3 years

166

4–7 years

241

8–11 years

233

12+ years

163

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause didn't work as expected in dogs?: 1,093 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 17 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Doxycycline 428 reports · 11% of its reports
Didn't work as expected after Cefovecin (Convenia) 584 reports · 15% of its reports
Didn't work as expected after Enrofloxacin (Baytril) 368 reports · 9.8% of its reports
Didn't work as expected after Metronidazole 407 reports · 13% of its reports
Didn't work as expected after Amoxicillin 145 reports · 11% of its reports
Didn't work as expected after Enrofloxacin + Silver Sulfadiazine 32 reports · 15% of its reports
Didn't work as expected after Enrofloxacin + Ketoconazole + Triamcinolone 20 reports · 21% of its reports

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with didn't work as expected