Swelling after Doxycycline in dogs

288 reports to the FDA describe swelling in dogs given Doxycycline. That is 7.2% of all reports for this medicine, compared with 2.8% across reports for all dog medicines, so it is reported unusually often with this medicine.

288Reports

55%Marked serious

7.3%Recovered

20%Died or euthanised

21 daysTypical onset

How soon it started

Same day

45 21%

1–2 days

22 10%

3–7 days

23 11%

1–4 weeks

37 17%

Over a month

91 42%

How the animals did

Recovered

21 7.3%

Still unwell when reported

143 50%

Died

27 9.4%

Euthanised

32 11%

Not known

65 23%

Problems reported at the same time

83 29%

74 26%

59 20%

51 18%

49 17%

43 15%

39 14%

Abnormal radiograph finding

38 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

111

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause swelling in dogs?: 288 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 21 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

Swelling after Amoxicillin + Clavulanate (Clavamox) 454 reports · 8.4% of its reports
Swelling after Cefovecin (Convenia) 362 reports · 9.6% of its reports
Swelling after Enrofloxacin (Baytril) 323 reports · 8.6% of its reports
Swelling after Metronidazole 238 reports · 7.7% of its reports
Swelling after Amoxicillin 76 reports · 5.6% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with swelling