Injection site reaction after Doxycycline in dogs

The FDA has received 104 reports of injection site reaction in dogs after Doxycycline. That is 2.6% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

104Reports
48%Marked serious
8.7%Recovered
9.6%Died or euthanised
35 daysTypical onset
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How soon it started

Same day
18 19%
1–2 days
3 3.1%
3–7 days
2 2.1%
1–4 weeks
17 18%
Over a month
57 59%

How the animals did

Recovered
9 8.7%
Still unwell when reported
61 59%
Died
1 1.0%
Euthanised
9 8.7%
Not known
24 23%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
53
4–7 years
26
8–11 years
15
12+ years
7

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause injection site reaction in dogs?
104 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 35 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

All reported side effects of Doxycycline in dogs · Medicines most reported with injection site reaction