Weight gain after Trilostane (Vetoryl) in dogs

390 reports to the FDA describe weight gain in dogs given Trilostane. That is 3.3% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

390Reports

44%Marked serious

6.4%Recovered

9.2%Died or euthanised

60 daysTypical onset

How soon it started

Same day

9 3.0%

1–2 days

5 1.7%

3–7 days

7 2.3%

1–4 weeks

70 23%

Over a month

210 70%

How the animals did

Recovered

22 5.6%

Recovered with lasting effects

3 0.8%

Still unwell when reported

51 13%

Died

10 2.6%

Euthanised

26 6.7%

Not known

278 71%

Problems reported at the same time

Liver problems

148 38%

Didn't work as expected

117 30%

64 16%

62 16%

59 15%

57 15%

53 14%

51 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

210

12+ years

112

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause weight gain in dogs?: 390 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 60 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weight gain with similar medicines

Weight gain after Insulin 29 reports · 0.4% of its reports
Weight gain after Levothyroxine 51 reports · 1.7% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with weight gain