Loose stool after Trilostane (Vetoryl) in dogs

The FDA has received 231 reports of loose stool in dogs after Trilostane. That is 1.9% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported unusually often with this medicine.

231Reports

62%Marked serious

22%Recovered

10.0%Died or euthanised

25 daysTypical onset

How soon it started

Same day

14 7.6%

1–2 days

18 9.7%

3–7 days

30 16%

1–4 weeks

41 22%

Over a month

82 44%

How the animals did

Recovered

50 22%

Still unwell when reported

41 18%

Died

4 1.7%

Euthanised

19 8.2%

Not known

117 51%

Problems reported at the same time

88 38%

72 31%

68 29%

60 26%

36 16%

35 15%

35 15%

33 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

113

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause loose stool in dogs?: 231 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 25 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loose stool with similar medicines

Loose stool after Insulin 54 reports · 0.7% of its reports
Loose stool after Phenylpropanolamine (Proin) 52 reports · 1.3% of its reports
Loose stool after Levothyroxine 55 reports · 1.8% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with loose stool