Leucocytosis after Trilostane (Vetoryl) in dogs

190 reports to the FDA describe leucocytosis in dogs given Trilostane. That is 1.6% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

190Reports

78%Marked serious

4.7%Recovered

29%Died or euthanised

44 daysTypical onset

How soon it started

Same day

7 4.8%

1–2 days

11 7.6%

3–7 days

11 7.6%

1–4 weeks

35 24%

Over a month

81 56%

How the animals did

Recovered

9 4.7%

Still unwell when reported

37 19%

Died

14 7.4%

Euthanised

42 22%

Not known

88 46%

Problems reported at the same time

112 59%

98 52%

88 46%

87 46%

81 43%

63 33%

57 30%

53 28%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause leucocytosis in dogs?: 190 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 44 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

Leucocytosis after Insulin 78 reports · 1.1% of its reports
Leucocytosis after Phenylpropanolamine (Proin) 47 reports · 1.1% of its reports
Leucocytosis after Levothyroxine 47 reports · 1.6% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with leucocytosis