Neutrophilia after Trilostane (Vetoryl) in dogs

159 reports to the FDA describe neutrophilia in dogs given Trilostane. That is 1.3% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

159Reports

80%Marked serious

3.1%Recovered

30%Died or euthanised

36 daysTypical onset

How soon it started

Same day

6 4.7%

1–2 days

4 3.1%

3–7 days

13 10%

1–4 weeks

34 27%

Over a month

70 55%

How the animals did

Recovered

5 3.1%

Still unwell when reported

31 19%

Died

11 6.9%

Euthanised

37 23%

Not known

75 47%

Problems reported at the same time

106 67%

78 49%

73 46%

68 43%

64 40%

63 40%

52 33%

49 31%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause neutrophilia in dogs?: 159 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 36 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutrophilia with similar medicines

Neutrophilia after Insulin 50 reports · 0.7% of its reports
Neutrophilia after Phenylpropanolamine (Proin) 25 reports · 0.6% of its reports
Neutrophilia after Levothyroxine 42 reports · 1.4% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with neutrophilia