Elevated amylase after Trilostane (Vetoryl) in dogs

135 reports to the FDA describe elevated amylase in dogs given Trilostane. That is 1.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

135Reports

71%Marked serious

8.1%Recovered

25%Died or euthanised

58 daysTypical onset

How soon it started

Same day

3 3.3%

1–2 days

2 2.2%

3–7 days

8 8.7%

1–4 weeks

24 26%

Over a month

55 60%

How the animals did

Recovered

9 6.7%

Recovered with lasting effects

2 1.5%

Still unwell when reported

24 18%

Died

10 7.4%

Euthanised

24 18%

Not known

66 49%

Problems reported at the same time

67 50%

64 47%

61 45%

54 40%

53 39%

46 34%

44 33%

35 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause elevated amylase in dogs?: 135 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 58 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated amylase with similar medicines

Elevated amylase after Insulin 45 reports · 0.6% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with elevated amylase