Elevated lipase after Trilostane (Vetoryl) in dogs

208 reports to the FDA describe elevated lipase in dogs given Trilostane. That is 1.7% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

208Reports

62%Marked serious

4.3%Recovered

14%Died or euthanised

61 daysTypical onset

How soon it started

Same day

4 2.6%

1–2 days

5 3.2%

3–7 days

13 8.3%

1–4 weeks

35 22%

Over a month

99 63%

How the animals did

Recovered

7 3.4%

Recovered with lasting effects

2 1.0%

Still unwell when reported

36 17%

Died

8 3.8%

Euthanised

22 11%

Not known

133 64%

Problems reported at the same time

119 57%

85 41%

76 37%

60 29%

56 27%

53 25%

52 25%

48 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause elevated lipase in dogs?: 208 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 61 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated lipase with similar medicines

Elevated lipase after Insulin 80 reports · 1.1% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with elevated lipase