Pancreatitis after Trilostane (Vetoryl) in dogs

254 reports to the FDA describe pancreatitis in dogs given Trilostane. That is 2.1% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

254Reports
82%Marked serious
13%Recovered
24%Died or euthanised
38 daysTypical onset
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How soon it started

Same day
5 2.5%
1–2 days
9 4.5%
3–7 days
20 9.9%
1–4 weeks
56 28%
Over a month
112 55%

How the animals did

Recovered
31 12%
Recovered with lasting effects
1 0.4%
Still unwell when reported
48 19%
Died
19 7.5%
Euthanised
41 16%
Not known
114 45%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
20
8–11 years
121
12+ years
104

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause pancreatitis in dogs?
254 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 38 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pancreatitis with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with pancreatitis