Stumbling gait after Selamectin (Revolution) in dogs

The FDA has received 32 reports of stumbling gait in dogs after Selamectin. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

32Reports

28%Marked serious

28%Recovered

19%Died or euthanised

Same dayTypical onset

How soon it started

Same day

10 53%

1–2 days

4 21%

3–7 days

4 21%

1–4 weeks

0 0.0%

Over a month

1 5.3%

How the animals did

Recovered

9 28%

Still unwell when reported

4 13%

Died

5 16%

Euthanised

1 3.1%

Not known

13 41%

Problems reported at the same time

15 47%

8 25%

8 25%

7 22%

6 19%

6 19%

6 19%

5 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause stumbling gait in dogs?: 32 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Stumbling gait with similar medicines

Stumbling gait after Ivermectin + Pyrantel (Heartgard Plus) 152 reports · 0.1% of its reports
Stumbling gait after Milbemycin Oxime + Spinosad (Trifexis) 236 reports · 0.2% of its reports
Stumbling gait after Moxidectin (ProHeart 6) 78 reports · 0.2% of its reports
Stumbling gait after Milbemycin Oxime + Praziquantel (Interceptor Plus) 63 reports · 0.2% of its reports
Stumbling gait after Milbemycin Oxime (Interceptor) 34 reports · 0.1% of its reports
Stumbling gait after Ivermectin (Heartgard) 65 reports · 0.5% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with stumbling gait