Stumbling gait after Moxidectin (ProHeart 6) in dogs

78 reports to the FDA describe stumbling gait in dogs given Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

78Reports

58%Marked serious

27%Recovered

17%Died or euthanised

Same dayTypical onset

How soon it started

Same day

35 61%

1–2 days

8 14%

3–7 days

5 8.8%

1–4 weeks

4 7.0%

Over a month

5 8.8%

How the animals did

Recovered

20 26%

Recovered with lasting effects

1 1.3%

Still unwell when reported

32 41%

Died

8 10%

Euthanised

5 6.4%

Not known

12 15%

Problems reported at the same time

30 38%

26 33%

20 26%

17 22%

17 22%

12 15%

11 14%

11 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause stumbling gait in dogs?: 78 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Stumbling gait with similar medicines

Stumbling gait after Ivermectin + Pyrantel (Heartgard Plus) 152 reports · 0.1% of its reports
Stumbling gait after Milbemycin Oxime + Spinosad (Trifexis) 236 reports · 0.2% of its reports
Stumbling gait after Milbemycin Oxime + Praziquantel (Interceptor Plus) 63 reports · 0.2% of its reports
Stumbling gait after Milbemycin Oxime (Interceptor) 34 reports · 0.1% of its reports
Stumbling gait after Selamectin (Revolution) 32 reports · 0.1% of its reports
Stumbling gait after Ivermectin (Heartgard) 65 reports · 0.5% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with stumbling gait