Skin redness after Selamectin (Revolution) in dogs

365 reports to the FDA describe skin redness in dogs given Selamectin. That is 1.2% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

365Reports

8.8%Marked serious

9.6%Recovered

1.1%Died or euthanised

1 daysTypical onset

How soon it started

Same day

65 42%

1–2 days

39 25%

3–7 days

20 13%

1–4 weeks

19 12%

Over a month

12 7.7%

How the animals did

Recovered

33 9.0%

Recovered with lasting effects

2 0.5%

Still unwell when reported

79 22%

Died

2 0.5%

Euthanised

2 0.5%

Not known

247 68%

Problems reported at the same time

Itching

129 35%

Application site reaction

104 28%

Hair loss

98 27%

Skin rash or irritation

45 12%

38 10%

34 9.3%

32 8.8%

28 7.7%

Age of the animals

Under 1 year

1–3 years

123

4–7 years

106

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause skin redness in dogs?: 365 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin redness with similar medicines

Skin redness after Ivermectin + Pyrantel (Heartgard Plus) 491 reports · 0.3% of its reports
Skin redness after Milbemycin Oxime + Spinosad (Trifexis) 828 reports · 0.6% of its reports
Skin redness after Moxidectin (ProHeart 6) 1,035 reports · 2.0% of its reports
Skin redness after Milbemycin Oxime + Praziquantel (Interceptor Plus) 163 reports · 0.5% of its reports
Skin redness after Milbemycin Oxime (Interceptor) 71 reports · 0.2% of its reports
Skin redness after Ivermectin (Heartgard) 105 reports · 0.9% of its reports
Skin redness after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 24 reports · 2.1% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with skin redness